dc.contributor.author | Koçyiğit, Ümit M. | |
dc.contributor.author | Taslimi, Parham | |
dc.contributor.author | Tüzün, Burak | |
dc.contributor.author | Yakan, Hasan | |
dc.contributor.author | Muglu, Halit | |
dc.contributor.author | Güzel, Emre | |
dc.date.accessioned | 2022-02-09T12:30:22Z | |
dc.date.available | 2022-02-09T12:30:22Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 0739-1102 | |
dc.identifier.issn | 1538-0254 | |
dc.identifier.uri | https://doi.org/10.1080/07391102.2020.1857842 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14002/388 | |
dc.description.abstract | In recent years, acetylcholinesterase (AChE) and alpha-glycosidase (alpha-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, cancer, and Alzheimer's. In this manner, the preparation and enzyme inhibition activities of peripherally 1,2,3-triazole group substituted metallophthalocyanine derivatives with strong absorption in the visible region were presented. These novel metallophthalocyanine derivatives (2-6) effectively inhibited AChE, with K-i values in the range of 40.11 +/- 5.61 to 78.27 +/- 15.42 mu M. For alpha-glycosidase, the most effective K-i values of compounds 1 and 2 were with K-i values of 16.11 +/- 3.13 and 18.31 +/- 2.42 mu M, respectively. Also, theoretical calculations were investigated to compare the chemical and biological activities of the ligand (1) and its metal complexes (2-6). Biological activities of 1 and its complexes against acetylcholinesterase for ID 4M0E (AChE) and alpha-glycosidase for ID 1R47 (alpha-gly) are calculated. Theoretical calculations were compatible with the experimental results and these 1,2,3-triazole substituted phthalocyanine metal complexes were found to be efficient inhibitors for anticholinesterase and antidiabetic enzymes. Communicated by Ramaswamy H. Sarma | en_US |
dc.description.sponsorship | Research Fund of the Sakarya University of Applied Sciences [2020-01-10-015]; TUBITAK ULAKBIM High Performance and Grid Computing Center (TR-Grid eInfrastructure)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) | en_US |
dc.description.sponsorship | This work was supported by Research Fund of the Sakarya University of Applied Sciences (Project Number: 2020-01-10-015) and TUBITAK ULAKBIM High Performance and Grid Computing Center (TR-Grid eInfrastructure). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Taylor & Francis Inc | en_US |
dc.relation.ispartof | Journal of Biomolecular Structure & Dynamics | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Phthalocyanine | en_US |
dc.subject | triazole | en_US |
dc.subject | enzyme inhibition | en_US |
dc.subject | molecular docking | en_US |
dc.subject | DFT studies | en_US |
dc.title | 1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies | en_US |
dc.type | article | en_US |
dc.authorid | Guzel, Emre / 0000-0002-1142-3936 | |
dc.authorid | TUZUN, BURAK / 0000-0002-0420-2043 | |
dc.department | Fakülteler, Teknoloji Fakültesi, Mühendislik Temel Bilimleri Bölümü | en_US |
dc.identifier.doi | 10.1080/07391102.2020.1857842 | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Guzel, Emre/H-2692-2018 | |
dc.authorscopusid | 57189006957 | |
dc.authorscopusid | 56658628800 | |
dc.authorscopusid | 56699974000 | |
dc.authorscopusid | 46462159400 | |
dc.authorscopusid | 56195892800 | |
dc.authorscopusid | 55579369300 | |
dc.identifier.wos | WOS:000597030900001 | en_US |
dc.identifier.scopus | 2-s2.0-85097366473 | en_US |
dc.identifier.pmid | 33292060 | en_US |