dc.contributor.author | Güzel, Emre | |
dc.contributor.author | Arslan, Barış Seçkin | |
dc.contributor.author | Çıkrıkçı, Kübra | |
dc.contributor.author | Ergun, Adem | |
dc.contributor.author | Gençer, Nahit | |
dc.contributor.author | Arslan, Oktay | |
dc.contributor.author | Nebioğlu, Mehmet | |
dc.date.accessioned | 2022-02-09T12:29:27Z | |
dc.date.available | 2022-02-09T12:29:27Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1088-4246 | |
dc.identifier.issn | 1099-1409 | |
dc.identifier.uri | https://doi.org/10.1142/S1088424620500170 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14002/266 | |
dc.description.abstract | The preparation and assessment of carbonic anhydrase and paraoxonase enzyme inhibition properties of 3-(2-(5-amino-4-(4-bromophenyl)-3-methyl-1H-pyrazol-1-yl)ethoxy)phthalonitrile (2) and its nitrogen-containing non-peripheral phthalocyanine derivatives (3 and 4) are reported for the first time. The new phthalonitrile and its phthalocyanine derivatives have been elucidated by FT-IR spectroscopy, H-1-NMR, C-13-NMR, mass and UV-vis spectroscopy. The results demonstrated that all synthesized compounds moderately inhibited carbonic anhydrase and paraoxonase enzymes. Among the compounds, the most active ones were found to be compound 4 for PON (Ki : 0.14 mu M), compound 3 for hCA I (Ki : 22.52 mu M) and compound 1 for hCA 11 (Ki : 13.62 mu M). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | World Sci Publ Co Inc | en_US |
dc.relation.ispartof | Journal of Porphyrins and Phthalocyanines | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | phthalocyanine | en_US |
dc.subject | metal complex | en_US |
dc.subject | aminopyrazole | en_US |
dc.subject | carbonic anhydrase | en_US |
dc.subject | paraoxonase | en_US |
dc.subject | inhibitor | en_US |
dc.subject | Langmuir-Blodgett-Films | en_US |
dc.subject | Photodynamic Therapy | en_US |
dc.subject | Iron Phthalocyanine | en_US |
dc.subject | Metal-Free | en_US |
dc.subject | Derivatives | en_US |
dc.subject | Zinc | en_US |
dc.subject | Photosensitizers | en_US |
dc.subject | Substituents | en_US |
dc.subject | Agents | en_US |
dc.title | Synthesis, in vitro inhibition effect of novel phthalocyanine complexes as carbonic anhydrase and paraoxonase enzyme inhibitors | en_US |
dc.type | article | en_US |
dc.authorid | Guzel, Emre / 0000-0002-1142-3936 | |
dc.authorid | Gencer, Nahit / 0000-0001-7092-8857 | |
dc.authorid | Ergun, Adem / 0000-0003-4647-6058 | |
dc.department | Fakülteler, Teknoloji Fakültesi, Mühendislik Temel Bilimleri Bölümü | en_US |
dc.identifier.doi | 10.1142/S1088424620500170 | |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.startpage | 1047 | en_US |
dc.identifier.endpage | 1053 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.authorwosid | Guzel, Emre/H-2692-2018 | |
dc.authorwosid | Gencer, Nahit/AAG-4507-2019 | |
dc.authorscopusid | 55579369300 | |
dc.authorscopusid | 57203098758 | |
dc.authorscopusid | 57218205822 | |
dc.authorscopusid | 55084270000 | |
dc.authorscopusid | 14055767700 | |
dc.authorscopusid | 35974671200 | |
dc.authorscopusid | 8300210100 | |
dc.identifier.wos | WOS:000559810800007 | en_US |
dc.identifier.scopus | 2-s2.0-85088268003 | en_US |