Yazar "Zengin Kurt, Belma" için listeleme
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Assessing cytotoxic activities, theoretical and in silico molecular docking calculations of phthalocyanines bearing cinnamyloxy-groups
Özten, Özge; Kuznetsov, Aleksey E.; Gokce, Mustafa; Erkan, Sultan; Bulut, Emrah; Taskin, Omer Suat; Zengin Kurt, Belma; Yıldız, Mustafa Zahid; Sobotta, Lukasz; Güzel, Emre (Taylor and Francis Ltd., 2023)Cancer has been recognized as one of the deadliest diseases in the world in recent years. By chemically tailoring specific properties, anticancer agents can be prepared very effectively for the treatment of various cancer ... -
A new series of asymmetric bis-isatin derivatives containing urea/thiourea moiety: Preparation, spectroscopic elucidation, antioxidant properties and theoretical calculations
Yakan, Hasan; Cavuş, M. Serdar; Zengin Kurt, Belma; Muglu, Halit; Sönmez, Fatih; Güzel, Emre (Elsevier, 2021)In the present study, design, synthesis, characterization, and investigation of antioxidant properties of novel asymmetric bis-isatin derivatives (1-8) containing urea/thiourea moiety are reported for the first time. FT-IR, ... -
Novel AChE and BChE inhibitors using combined virtual screening, text mining and in vitro binding assays
Şahin, Kader; Zengin Kurt, Belma; Sönmez, Fatih; Durdağı, Serdar (Taylor & Francis Inc, 2020)In the current work, we developed a computational pipeline method for predicting the binding affinities of studied compounds at the specific target sites. Since many approved therapeutic compounds involve indole or ... -
Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Tokgöz, Merve Nur; Öztürk Civelek, Dilek; Tuncay, Fulya Oz; Cakmak, Ummuhan; Kolcuoğlu, Yakup; Akdemir, Atilla; Sönmez, Fatih (John Wiley and Sons Inc, 2023)Totally 15 novel flurbiprofen urea derivatives were synthesized bearing the thiadiazole ring. Their inhibition effects on tyrosinase were determined. 3c was found to be the strongest inhibitor with the IC50 value of 68.0 ... -
Synthesis of naproxen thiadiazole urea hybrids and determination of their anti-melanoma, anti-migration, tyrosinase inhibitory activity, and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Gökçe, Mustafa; Çakmak, Ümmühan; Tuncay, Fülya Öz; Kolcuoğlu, Yakup; Günaydın Akyıldız, Ayşenur; Akdemir, Atilla; Öztürk Civelek, Dilek; Sönmez, Fatih (Elsevier B.V., 2024)Novel sixteen naproxen urea compounds were synthesized bearing the thiadiazole ring. Their inhibitory activities against tyrosinase were investigated. 3o was discovered to be the most potent inhibitor of tyrosinase, with ...