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Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Tokgöz, Merve Nur; Öztürk Civelek, Dilek; Tuncay, Fulya Oz; Cakmak, Ummuhan; Kolcuoğlu, Yakup; Akdemir, Atilla; Sönmez, Fatih (John Wiley and Sons Inc, 2023)Totally 15 novel flurbiprofen urea derivatives were synthesized bearing the thiadiazole ring. Their inhibition effects on tyrosinase were determined. 3c was found to be the strongest inhibitor with the IC50 value of 68.0 ...