Yazar "Sönmez, Fatih" için listeleme
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Comparative assessment of structure-property relationships of new Cu(II) complex in selected density functionals
Avcı, Davut; Cömert, Hatice Esra; Sönmez, Fatih; Dege, Necmi; Tamer, Ömer; Atalay, Yusuf (ELSEVIER, 2024)In order to evaluate the structure-property relationships of Cu(II) complex by using DFT methods, the structure of the newly synthesized Cu(II) complex, [Cu(6-Brpic)2(bpy)], was investigated by XRD, FTIR, UV-Vis, and ... -
Concentration effects on optical properties, DFT, crystal characterization and alpha-glucosidase activity studies: Novel Zn(II) complex
Değe, Necmi; Özge, Özgen; Avcı, Davut; Başoğlu, Adil; Sönmez, Fatih; Yaman, Mavise; Kurt, Belma Zengin (Pergamon-Elsevier Science Ltd, 2021)A novel Zn(II) complex of 6-ClpicH and picH was synthesized and its structure was determined by XRD technique. The detailed experimental optical susceptibility and band gap, refractive index, linear polarizability, optical ... -
Evaluation of carbonic anhydrase and paraoxonase inhibition activities and molecular docking studies of highly water-soluble sulfonated phthalocyanines
Güzel, Emre; Sönmez, Fatih; Erkan, Sultan; Çıkrıkçı, Kübra; Ergun, Adem; Gençer, Nahit; Koçak, Makbule B. (Scientific Technical Research Council Turkey-Tubitak, 2020)The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy ... -
Hepatosellüler karsinomda fotodinamik tedavinin potansiyel terapötik etkisinin araştırılması
Özten, Özge (Sakarya Uygulamalı Bilimler Üniversitesi, 2021)Hepatosellüler karsinom (HSK) dünya çapında yaygın olarak gözlemlenen heterojen yapılı bir kanser türüdür. Tümörün agresif yapısından dolayı HSK tedavisinde kullanılan cerrahi, kemoradyoterapi ve çeşitli kemoterapik ilaçlar ... -
In vitro α-glucosidase, docking and density functional theory studies on novel azide metal complexes
Avcı, Davut; Özge, Özgen; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (Taylor and Francis Ltd., 2024)Aim: The goal of this study is to synthesize new metal complexes containing N-methyl-1-(pyridin-2-yl)methanimine and azide ligands as α-glucosidase inhibitors for Type 2 diabetes. Materials & methods: The target complexes ... -
Investigation of the therapeutic effect of 5-aminolevulinic acid based photodynamic therapy on hepatocellular carcinoma
Özten, Özge; Eskiler, Gamze Güney; Sönmez, Fatih; Yıldız, Mustafa Zahid (Springer London Ltd, 2021)Hepatocellular carcinoma (HCC) is a heterogeneous type of cancer and current treatment options limit successful therapy outcomes. Photodynamic therapy (PDT) has attracted attention as an alternative approach in the treatment ... -
New Schiff bases based on isatin and (thio)/carbohydrazone: preparation, experimental–theoretical spectroscopic characterization, and DFT approach to antioxidant characteristics
Muğlu, Halit; Sönmez, Fatih; Çavuş, M. Serda; Kurt, Belma Z.; Yakan, Hasan (Springer Science and Business Media B.V., 2023)In this study, synthesis, spectroscopic elucidation, and investigation of antioxidant properties of new Schiff bases based on isatin and (thio)/carbohydrazone derivatives have been reported for the first time. The structures ... -
New Schiff bases based on isatin and (thio)/carbohydrazone: preparation, experimental–theoretical spectroscopic characterization, and DFT approach to antioxidant characteristics
Muğlu, Halit; Sönmez, Fatih; Çavuş, M. Serdar; Kurt, Belma Z.; Yakan, Hasan (Springer Science and Business Media B.V., 2023)In this study, synthesis, spectroscopic elucidation, and investigation of antioxidant properties of new Schiff bases based on isatin and (thio)/carbohydrazone derivatives have been reported for the first time. The structures ... -
A new series of asymmetric bis-isatin derivatives containing urea/thiourea moiety: Preparation, spectroscopic elucidation, antioxidant properties and theoretical calculations
Yakan, Hasan; Cavuş, M. Serdar; Zengin Kurt, Belma; Muglu, Halit; Sönmez, Fatih; Güzel, Emre (Elsevier, 2021)In the present study, design, synthesis, characterization, and investigation of antioxidant properties of novel asymmetric bis-isatin derivatives (1-8) containing urea/thiourea moiety are reported for the first time. FT-IR, ... -
Novel AChE and BChE inhibitors using combined virtual screening, text mining and in vitro binding assays
Şahin, Kader; Zengin Kurt, Belma; Sönmez, Fatih; Durdağı, Serdar (Taylor & Francis Inc, 2020)In the current work, we developed a computational pipeline method for predicting the binding affinities of studied compounds at the specific target sites. Since many approved therapeutic compounds involve indole or ... -
Novel Cu(II), Co(II) and Zn(II) metal complexes with mixed-ligand: Synthesis, crystal structure, alpha-glucosidase inhibition, DFT calculations, and molecular docking
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Değe, Necmi (Elsevier, 2019)Novel Cu(II), Co(II) and Zn(II) metal complexes containing 6-methylpyridine-2-carboxylic acid and 2,2'-dipyridylamine {[Cu(6-mpa)(dipya)(OAc)] center dot 3H(2)O (1), [Co(6-mpa)(dipya)Cl-2]center dot 2H(2)O (2), ... -
Novel Cu(II), Co(II) and Zn(II) metal complexes with mixed-ligand: Synthesis, crystal structure, alpha-glucosidase inhibition, DFT calculations, and molecular docking (vol 1197, pg 645, 2019)
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğulu, Adil; Atalay, Yusuf; Değe, Necmi (Elsevier, 2021)[No Abstract Available] -
Novel metal complexes containing 6-methylpyridine-2-carboxylic acid as potent a-glucosidase inhibitor: synthesis, crystal structures, DFT calculations, and molecular docking (vol 25, pg 171, 2021)
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Değe, Necmi (Springer, 2021)[No Abstract Available] -
Novel metal complexes containing 6-methylpyridine-2-carboxylic acid as potent alpha-glucosidase inhibitor: synthesis, crystal structures, DFT calculations, and molecular docking
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Değe, Necmi (Springer, 2021)The World Health Organization (WHO) report shows that diabetes mellitus (DM) will be one of the ten deadly diseases in the near future. The best way to prevent DM is to decrease blood glucose levels and keep under control; ... -
Novel schiff base-azide metal complexes: Synthesis, spectral, nonlinear optics, and DFT studies
Avcı, Davut; Özge, Özgen; Sönmez, Fatih; Başoğlu, Adil; Tamer, Ömer; Atalay, Yusuf (Elsevier Ltd, 2024)In order to enhance nonlinear optics (NLO)-based technologies, current research focuses on the design and synthesis of coordination materials. In this context, to investigate spectral and theoretical linear optical ... -
A novel series of mixed-ligand M(II) complexes containing 2,2 '-bipyridyl as potent alpha-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Değe, Necmi (Springer, 2019)Diabetes mellitus (DM) is a common degenerative disease and characterized by high blood glucose levels. Since the effective antidiabetic treatments attempt to decrease blood glucose levels, keeping glucose under control ... -
A novel series of mixed-ligand M(II) complexes containing 2,2 '-bipyridyl as potent alpha-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking (vol 24, pg 747, 2019)
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Değe, Necmi (Springer, 2021)[No Abstract Available] -
Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies
Çakmak, Elmas Begüm; Kurt, Belma Zengin; Civelek, Dilek Özturk; Angeli, Andrea; Akdemir, Atilla; Sönmez, Fatih; Kücükislamoğlu, Mustafa (Academic Press Inc Elsevier Science, 2021)Carbonic anhydrase (CA) IX, and XII isoforms are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for some cancers because it is overexpressed in hypoxic tumors and this ... -
Rabbit muscle pyruvate kinase activators: Synthesis, molecular docking and theoretical studies of N-substituted sulfonamide derivatives
Kaya, Mustafa Oğuzhan; Demirci, Tuna; Musatat, Ahmad Badreddin; Özdemir, Oğuzhan; Sönmez, Fatih; Kaya, Yeşim; Arslan, Mustafa (Elsevier B.V., 2024)Pyruvate kinase (PK) activators have potential therapeutic applications in diseases such as sickle cell anemia. In this study, N-Substituted sulfonamide derivatives of 1,4-dihydropyridines were synthesized and evaluated ... -
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies
Kurt, Belma Zengin; Sönmez, Fatih; Öztürk, Dilek; Akdemir, Atilla; Angeli, Andrea; Supuran, Claudiu T. (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)Carbonic anhydrases isoforms CA IX, and XII are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for especially colorectal cancers, because it is overexpressed in colorectal ...