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Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma
Kurt, Belma Zengin; Dağ, Aydan; Doğan, Berna; Durdağı, Serdar; Angeli, Andrea; Nocentini, Alessio; Sönmez, Fatih (Academic Press Inc Elsevier Science, 2019)A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII ...