Yazar "Kurt, Belma Zengin" için listeleme
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Concentration effects on optical properties, DFT, crystal characterization and alpha-glucosidase activity studies: Novel Zn(II) complex
Değe, Necmi; Özge, Özgen; Avcı, Davut; Başoğlu, Adil; Sönmez, Fatih; Yaman, Mavise; Kurt, Belma Zengin (Pergamon-Elsevier Science Ltd, 2021)A novel Zn(II) complex of 6-ClpicH and picH was synthesized and its structure was determined by XRD technique. The detailed experimental optical susceptibility and band gap, refractive index, linear polarizability, optical ... -
In vitro α-glucosidase, docking and density functional theory studies on novel azide metal complexes
Avcı, Davut; Özge, Özgen; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (Taylor and Francis Ltd., 2024)Aim: The goal of this study is to synthesize new metal complexes containing N-methyl-1-(pyridin-2-yl)methanimine and azide ligands as α-glucosidase inhibitors for Type 2 diabetes. Materials & methods: The target complexes ... -
Preparation, antioxidant activity, and theoretical studies on the relationship between antioxidant and electronic properties of bis(thio/carbohydrazone) derivatives
Muglu, Halit; Kurt, Belma Zengin; Sonmez, Fatih; Guzel, Emre; Cavul, M. Serdar; Yakan, Hasan (Pergamon-Elsevier Science Ltd, 2022)A series of novel bis(thio/carbohydrazone) compounds has been prepared from (thio)/carbohydrazide and various aldehyde derivatives. FTIR, H-1 and C-13 NMR spectroscopy, and elemental analysis have been used to elucidate ... -
Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies
Çakmak, Elmas Begüm; Kurt, Belma Zengin; Civelek, Dilek Özturk; Angeli, Andrea; Akdemir, Atilla; Sönmez, Fatih; Kücükislamoğlu, Mustafa (Academic Press Inc Elsevier Science, 2021)Carbonic anhydrase (CA) IX, and XII isoforms are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for some cancers because it is overexpressed in hypoxic tumors and this ... -
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies
Kurt, Belma Zengin; Sönmez, Fatih; Öztürk, Dilek; Akdemir, Atilla; Angeli, Andrea; Supuran, Claudiu T. (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)Carbonic anhydrases isoforms CA IX, and XII are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for especially colorectal cancers, because it is overexpressed in colorectal ... -
Synthesis, anticholinesterase activity and molecular modeling studies of novel carvacrol-substituted amide derivatives
Kurt, Belma Zengin; Durdağı, Serdar; Çelebi, Gülsen; Salmas, Ramin Ekhteiari; Sönmez, Fatih (Taylor & Francis Inc, 2020)In the present study, 23 novel carvacrol derivatives involving the amide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and tested in vitro as acetylcholinesterase (AChE) and ... -
Synthesis, antioxidant activity and SAR study of novel spiro-isatin-based Schiff bases
Sönmez, Fatih; Günesli, Zuhal; Kurt, Belma Zengin; Gazioğlu, Işıl; Avcı, Davut; Kücükislamoğlu, Mustafa (Springer, 2019)A new series of 21 Schiff bases of spiro-isatin was synthesized, and their DPPH, CUPRAC and ABTS cation radical scavenging abilities were investigated for antioxidant activity. The results showed that all the synthesized ... -
Synthesis, biological activity and multiscale molecular modeling studies of bis-coumarins as selective carbonic anhydrase IX and XII inhibitors with effective cytotoxicity against hepatocellular carcinoma
Kurt, Belma Zengin; Dağ, Aydan; Doğan, Berna; Durdağı, Serdar; Angeli, Andrea; Nocentini, Alessio; Sönmez, Fatih (Academic Press Inc Elsevier Science, 2019)A series of novel bis-coumarin derivatives containing triazole moiety as a linker between the alkyl chains was synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms I, II, IX and XII ... -
Synthesis, DFT calculations and molecular docking study of mixed ligand metal complexes containing 4,4 '-dimethyl-2,2 '-bipyridyl as alpha-glucosidase inhibitors
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (Elsevier, 2020)Novel mixed ligand metal complexes including 4,4'-dimethyl-2,2'-bipyridyl (dmdpy) and 6-methylpyridine-2-carboxylic acid (6-mpaH) {[VO(6-mpa)(dmdpy)]center dot SO3, (1), [Fe(6-mpa)(dmdpy)(NO3)(2)]center dot NO3, (2), ... -
Synthesis, DFT calculations and molecular docking study of mixed ligand metal complexes containing 4,4 '-dimethyl-2,2 '-bipyridyl as alpha-glucosidase inhibitors (vol 1205, 127655, 2020)
Avcı, Davut; Altürk, Sümeyye; Sönmez, Fatih; Tamer, Ömer; Başoğlu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (Elsevier, 2021)[No Abstract Available] -
Synthesis, DFT calculations, alpha-glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate
Ozge, Ozgen; Avci, Davut; Sonmez, Fatih; Tamer, Oemer; Dege, Necm; Basoglu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (WILEY, 2023)Diabetes is one of the fastest growing global health crises of the 21st century. One of the current therapeutic approaches used in the treatment of diabetes involves the suppression of carbohydrate hydrolyzing enzymes such ... -
Synthesis, DFT calculations, α-glucosidase inhibitor activity, and docking studies on Schiff base metal complexes containing isothiocyanate
Özge, Özgen; Avcı, Davut; Sönmez, Fatih; Tamer, Ömer; Dege, Necmi; Başoğlu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (John Wiley and Sons Ltd, 2023)Diabetes is one of the fastest growing global health crises of the 21st century. One of the current therapeutic approaches used in the treatment of diabetes involves the suppression of carbohydrate hydrolyzing enzymes such ... -
Synthesis, molecular docking and molecular dynamics studies of novel tacrine-carbamate derivatives as potent cholinesterase inhibitors
Özten, Özge; Kurt, Belma Zengin; Sönmez, Fatih; Doğan, Berna; Durdağı, Serdar (Academic Press Inc Elsevier Science, 2021)In the present study, new tacrine derivatives containing carbamate group were synthesized and their acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibition activities were evaluated. All synthesized compounds ... -
Synthesis, spectral properties, in vitro alpha-glucosidase inhibitory activity and quantum chemical calculations of novel mixed-ligand M(II) complexes containing 1,10-phenanthroline (vol 34, e5412, 2020)
Avci, Davut; Alturk, Sumeyye; Sonmez, Fatih; Tamer, Omer; Basoglu, Adil; Atalay, Yusuf; Kurt, Belma Zengin (Wiley, 2022)[Abstract Not Available]