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Assessing cytotoxic activities, theoretical and in silico molecular docking calculations of phthalocyanines bearing cinnamyloxy-groups
Özten, Özge; Kuznetsov, Aleksey E.; Gokce, Mustafa; Erkan, Sultan; Bulut, Emrah; Taskin, Omer Suat; Zengin Kurt, Belma; Yıldız, Mustafa Zahid; Sobotta, Lukasz; Güzel, Emre (Taylor and Francis Ltd., 2023)Cancer has been recognized as one of the deadliest diseases in the world in recent years. By chemically tailoring specific properties, anticancer agents can be prepared very effectively for the treatment of various cancer ... -
Biologically active phthalocyanine metal complexes: Preparation, evaluation of alpha-glycosidase and anticholinesterase enzyme inhibition activities, and molecular docking studies
Güzel, Emre; Koçyiğit, Ümit M.; Taslimi, Parham; Erkan, Sultan; Taşkın, Ömer S. (Wiley, 2021)In this study, preparation, as well as investigation of alpha-glycosidase and cholinesterase (ChE) enzyme inhibition activities of furan-2-ylmethoxy-substituted compounds 1-7, are reported. Peripherally, tetra-substituted ... -
Evaluation of carbonic anhydrase and paraoxonase inhibition activities and molecular docking studies of highly water-soluble sulfonated phthalocyanines
Güzel, Emre; Sönmez, Fatih; Erkan, Sultan; Çıkrıkçı, Kübra; Ergun, Adem; Gençer, Nahit; Koçak, Makbule B. (Scientific Technical Research Council Turkey-Tubitak, 2020)The investigation of carbonic anhydrase and paraoxonase enzyme inhibition properties of water-soluble zinc and gallium phthalocyanine complexes (1 and 2) are reported for the first time. The binding of p-sulfonylphenoxy ... -
Phthalocyanine complexes with (4-isopropylbenzyl)oxy substituents: preparation and evaluation of anti-carbonic anhydrase, anticholinesterase enzymes and molecular docking studies
Güzel, Emre; Koçyiğit, Ümit M.; Taslimi, Parham; Gülçin, İlhami; Erkan, Sultan; Nebioğlu, Mehmet; Şişman, İlkay (Taylor & Francis Inc, 2020)In this study, the preparation, aggregation behavior and investigation of carbonic anhydrase and cholinesterase enzyme inhibition features of non-peripherally (4-isopropylbenzyl)oxy-substituted phthalocyanines (4-6) are ... -
Potential thiosemicarbazone-based enzyme inhibitors: Assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan, Hasan; Kocyigit, Umit M.; Muglu, Halit; Ergul, Mustafa; Erkan, Sultan; Guzel, Emre; Taslimi, Parham (Wiley, 2022)A new series of thiosemicarbazone derivatives (1-11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ...