Yazar "Akdemir, Atilla" için listeleme
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Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies
Çakmak, Elmas Begüm; Kurt, Belma Zengin; Civelek, Dilek Özturk; Angeli, Andrea; Akdemir, Atilla; Sönmez, Fatih; Kücükislamoğlu, Mustafa (Academic Press Inc Elsevier Science, 2021)Carbonic anhydrase (CA) IX, and XII isoforms are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for some cancers because it is overexpressed in hypoxic tumors and this ... -
Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies
Kurt, Belma Zengin; Sönmez, Fatih; Öztürk, Dilek; Akdemir, Atilla; Angeli, Andrea; Supuran, Claudiu T. (Elsevier France-Editions Scientifiques Medicales Elsevier, 2019)Carbonic anhydrases isoforms CA IX, and XII are known to be highly expressed in various human tissues and malignancies. CA IX is a prominent target for especially colorectal cancers, because it is overexpressed in colorectal ... -
Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Tokgöz, Merve Nur; Öztürk Civelek, Dilek; Tuncay, Fulya Oz; Cakmak, Ummuhan; Kolcuoğlu, Yakup; Akdemir, Atilla; Sönmez, Fatih (John Wiley and Sons Inc, 2023)Totally 15 novel flurbiprofen urea derivatives were synthesized bearing the thiadiazole ring. Their inhibition effects on tyrosinase were determined. 3c was found to be the strongest inhibitor with the IC50 value of 68.0 ... -
Synthesis of naproxen thiadiazole urea hybrids and determination of their anti-melanoma, anti-migration, tyrosinase inhibitory activity, and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Gökçe, Mustafa; Çakmak, Ümmühan; Tuncay, Fülya Öz; Kolcuoğlu, Yakup; Günaydın Akyıldız, Ayşenur; Akdemir, Atilla; Öztürk Civelek, Dilek; Sönmez, Fatih (Elsevier B.V., 2024)Novel sixteen naproxen urea compounds were synthesized bearing the thiadiazole ring. Their inhibitory activities against tyrosinase were investigated. 3o was discovered to be the most potent inhibitor of tyrosinase, with ...