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Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Tokgöz, Merve Nur; Öztürk Civelek, Dilek; Tuncay, Fulya Oz; Cakmak, Ummuhan; Kolcuoğlu, Yakup; Akdemir, Atilla; Sönmez, Fatih (John Wiley and Sons Inc, 2023)Totally 15 novel flurbiprofen urea derivatives were synthesized bearing the thiadiazole ring. Their inhibition effects on tyrosinase were determined. 3c was found to be the strongest inhibitor with the IC50 value of 68.0 ... -
Synthesis of naproxen thiadiazole urea hybrids and determination of their anti-melanoma, anti-migration, tyrosinase inhibitory activity, and molecular docking studies
Zengin Kurt, Belma; Altundağ, Özlem; Gökçe, Mustafa; Çakmak, Ümmühan; Tuncay, Fülya Öz; Kolcuoğlu, Yakup; Günaydın Akyıldız, Ayşenur; Akdemir, Atilla; Öztürk Civelek, Dilek; Sönmez, Fatih (Elsevier B.V., 2024)Novel sixteen naproxen urea compounds were synthesized bearing the thiadiazole ring. Their inhibitory activities against tyrosinase were investigated. 3o was discovered to be the most potent inhibitor of tyrosinase, with ...